Imaging in Systems Biology

Sean G. Megason^{1, ,} and Scott E. Fraser^{1, ,}

¹Beckman Institute and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA

Available online 6 September 2007.

Most systems biology approaches involve determining the structure of biological circuits using genomewide “-omic” analyses. Yet imaging offers the unique advantage of watching biological circuits function over time at single-cell resolution in the intact animal. Here, we discuss the power of integrating imaging tools with more conventional -omic approaches to analyze the biological circuits of microorganisms, plants, and animals.

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